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Description
Bemarituzumab (bema), a first-in-class humanized IgG1 monoclonal antibody, selectively binds to 2b Isoform of thefibroblast growth factor receptor (FGFR2b). Bemarituzumab (FPA144) is a first-in-class humanized immunoglobulin G1 monoclonal antibody specific to the splice-variant FGFR2b that inhibits binding of the ligands FGF7, FGF10, and FGF22. Specifically, bemarituzumab does not inhibit binding of FGF23, the ligand responsible for phosphate and vitamin D metabolism, thereby potentially avoiding the risk of hyperphosphatemia associated with pan-FGFR tyrosine kinase inhibitors. Bemarituzumab is also glycoengineered for increased affinity for the human Fc gamma RIIIA receptor expressed on natural killer cells, enabling enhanced antibody-dependent cellmediated cytotoxicity.
Catalog No.
DHD47901
Host species
Humanized
Species reactivity
Human
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
1 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG1-kappa
Applications
Research Grade Biosimilar
Target
K-sam, KSAM, CD332, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2, FGFR-2, FGFR2, KGFR, BEK
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
XtenCHO
Accession
P21802
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
FPA144 ,FPA-144, FPA114-A, CAS: 1952272-74-0
Note
For research use only. Not suitable for clinical or therapeutic use.
关键字： Bemarituzumab;贝马里妥珠单抗;1952272-74-0;K-sam, KSAM;FGFR2, KGFR;
武汉佰乐博生物（Biolab Reagents）始创于 2021 年，核心创始团队由五位毕业于武汉大学、华中科技大学、华中农业大学等高校的生命科学领域顶尖研究者组成，团队深耕行业二十载，积淀了扎实的产品开发实力与技术应用经验，筑牢企业核心技术根基。
公司是国家高新技术企业、国家科技型中小企业，国家创新型中小企业，技术实力获权威认可，还通过 ISO9001、ISO13485 双质量管理体系认证，以标准化品控筑牢产品品质。依托全球领先技术平台，公司专注高品质生物试剂的全球化开发与整合，是法国 AntibodySystem 亚洲独家授权合作伙伴以及生工生物KleanAB品牌的合作伙伴，现构建起近 60000 种试剂的产品矩阵，核心涵盖蛋白、抗体、试剂盒，重点覆盖肿瘤、神经系统，病原菌感染等疾病研究领域，满足多元科研需求。
自成立以来，佰乐博生物始终为科研工作者、生物医药工业客户提供专业的产品与技术支持，以优质科研工具赋能科研，助力生命科学研究创新发展、深度突破。