Host:Rabbit
Target Protein:GRP94
IR:Immunogen Range:501-600/803
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7184
Swiss Prot:P14625
Source:KLH conjugated synthetic peptide derived from human GRP94:501-600/803
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Glucose regulated protein 94 (GRP 94) is a resident protein of the endoplasmic reticulum (ER) and is induced by the accumulation of unfolded proteins suggesting that it might associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP 94 and other resident ER proteins including GRP 78 and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. GRP 94 is also a low affinity, high capacity calcium binding protein, though it's role, if any, in calcium regulation is not understood.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:400-800)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
Sheep
.
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： HSP gp96;Endoplasmin;TRA1;gp96;gp96 homolog;
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