Trans-3-Hydroxy-L-proline is a hydroxylated derivative of the amino acid proline, specifically hydroxylated at the 3-position in the trans configuration. It is a non-proteinogenic amino acid that occurs naturally in certain biological systems, especially in collagen, where it plays a key role in stabilizing the triple-helical structure. Unlike the more common 4-hydroxyproline, which is abundant in animal collagen, trans-3-hydroxy-L-proline is found in specific collagen types and plant cell wall proteins such as extensins.
Structurally, it retains the pyrrolidine ring of proline but with an additional hydroxyl group at the third carbon. This modification impacts its conformational flexibility and hydrogen bonding capability, influencing protein folding and stability. Due to these characteristics, trans-3-hydroxy-L-proline is of interest in biomedical research, especially in the study of collagen-related diseases and in the design of collagen-mimetic peptides.
In synthetic chemistry and pharmaceutical development, this compound is also used as a chiral building block. Its stereochemistry and functional groups allow for selective derivatization, making it valuable in asymmetric synthesis and peptide engineering.
关键字： amino acid proline;pharmaceutical ;
武汉恒和达生物医药有限公司成立于2013年，公司总部位于武汉经济技术开发区民营科技工业园，为湖北省高新技术企业，主要从事原料药、高端医药中间体和精细化工产品的研发与生产，以及新化合物的技术咨询和检测等服务。恒和达生物目前拥有1000平米的研发及中试平台，并配备了各种现代化的实验研究设备，满足了各种化合物的小试研究，中试放大的生产。合作生产基地占地30余亩，配备了成套大型不锈钢和搪玻璃生产设备，反应釜设备从50L到2000L不等，具有吨位级的研发生产能力。