Rabbit Anti-phospho-STAT3 (Ser727) Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-STAT3 (Ser727)
IR:Immunogen Range:PM(p-S)PR
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:6774
Swiss Prot:P40763
Source:KLH conjugated Synthesised phosphopeptide derived from human STAT3 around the phosphorylation site of Ser727:PM(p-S)PR
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:100-200)
IHC-F(1:100-200)
Flow-Cyt(2ug/Test)
ICC(1:50-100)
Cross Reactive Species:Human
Rat
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： phospho-STAT3 (Ser72;STAT3 (phospho S727);p-STAT3 (phospho S72;STAT3(Phospho Ser727;STAT3(Phospho S727);p-STAT3(Ser727);Acute Phase Response;APRF;
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