Rabbit Anti-VSIG4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:VSIG4
IR:Immunogen Range:81-160/399
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:11326
Swiss Prot:Q9Y279
Source:KLH conjugated synthetic peptide derived from human VSIG4:81-160/399
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 familyrelated protein V-set and Ig domaincontaining 4 (VSIG4). Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th celldependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： VSIG4;V-set and immunoglob;domain;containing ;protein 4;CRIg;Z39IG;VSIG4_HUMAN;
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