Rabbit Anti-MDM2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:MDM2
IR:Immunogen Range:401-490/490
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4193
Swiss Prot:Q00987
Source:KLH conjugated synthetic peptide derived from human MDM2 :401-490/490
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. Interacts with CDKN2AIP, MTBP, TRBG1 and USP7. Isoform Mdm2-F does not interact with TP53/p53. Interacts with PYHIN1. Interacts with, and ubiquitinates HIV-1 Tat. Belongs to the MDM2/MDM4 family.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： MDM2;Double minute 2 prot;Mdm2 transformed 3T3;HDM2;MDM2BP;Mouse Double Minute ;MTBP;MDM2_HUMAN;
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