Rabbit Anti-MSH6 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:MSH6
IR:Immunogen Range:812-910/1360
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2956
Swiss Prot:P52701
Source:KLH conjugated synthetic peptide derived from human MSH6:812-910/1360
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Rabbit
Sheep
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： MSH6;DNA mismatch repair ;G/T mismatch binding;GTBP;GTMBP;HNPCC 5;HSAP;MSH6_HUMAN;
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