Rabbit Anti-Kir6.2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Kir6.2
IR:Immunogen Range:301-390/390
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3767
Swiss Prot:Q14654
Source:KLH conjugated synthetic peptide derived from human Kir62:301-390/390
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(3ug/test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Rabbit
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Kir6.2;mBIR;BIR;HHF 2;HHF2;IKATP;KCNJ11;IRK11_HUMAN;
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