Rabbit Anti-TPH2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:TPH2
IR:Immunogen Range:201-300/490
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:121278
Swiss Prot:Q8IWU9
Source:KLH conjugated synthetic peptide derived from human TPH2:201-300/490
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and tryptophan hydroxylase 2 (TPH2) comprise a small family of monooxygenases that catalyze the rate-limiting step in the catabolism of aromatic L-amino acids and utilize tetrahydropterine as a cofactor. TPH2 is highly expressed in the central nervous system (CNS), mainly in the brain. TPH2 catalyzes the first step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland, and may be involved in the pathology of several neuropsychiatric disorders. Glucocorticoid-mediated reduction of TPH2 is associated with the etiology of mood disorders, specifically psychotic major depression, and TPH2 may be related to dysregulation of serotonin neurotransmission in the brain which commonly leads to suicidal behavior.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
Horse
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： TPH2;ADHD7;NTPH; TPH 2;Tph2;TPH2_HUMAN;Tryptophan 5-hydroxy;Tryptophan hydroxyla;
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