Rabbit Anti-Phospho-Serine/Threonine Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-Serine/Threonine
IR:Immunogen Range:(p-S)(p-T)-NH2
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:407-41-0
Swiss Prot:N/A
Source:KLH conjugated synthesised phosphopeptide contain Phosphoserine and Phosphothreonine:(p-S)(p-T)-NH2
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kinases, but also those that are recognized by phosphorylation-dependent binding proteins like 14-3-3. These modular phosphoprotein interacting domains are critical elements in modulating, directing and amplifying intracellular communications. Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine surrounded by phenylalanine or tyrosine. For example, Akt, an important kinase that regulates cell survival, is activated by phosphorylation at Ser473, a site surrounded by phenylalanine and tyrosine. RSK1, p70 S6 K, and certain PKC isoforms also contain a similar consensus phosphorylation site. Phosphorylation of these sites is required for kinase activity. The Phospho-(Ser/Thr) Phe Antibody is a powerful tool for discovery of new proteins containing this important regulatory motif.
Size:50ul
Concentration:1mg/ml
Applications:IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:.
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Phospho-Serine/Threo;Phosphoserine/threon;hospho-Ser/Phospho-T;pan phospho-Ser/Phos; pan-phospho-Ser/Pho;pS/pT;p-S/p-T; pSER/pThr;
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