Rabbit Anti-HCN2 + HCN4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:HCN2 + HCN4
IR:Immunogen Range:151-250/889
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:610
Swiss Prot:Q9UL51
Source:KLH conjugated synthetic peptide derived from human HCN2 + HCN4:151-250/889
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
Rabbit
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： HCN2 + HCN4;HCN2 / HCN4;HCN2+4;BCNG 2;HCN 1;HCN 4;HCN2_HUMAN;HCN4_HUMAN;
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