Rabbit Anti-APOL1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:APOL1
IR:Immunogen Range:201-300/398
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8542
Swiss Prot:O14791
Source:KLH conjugated synthetic peptide derived from human APOL1/Apolipoprotein L:201-300/398
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Apolipoproteins are protein components of plasma lipoproteins (1). The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI, which are associated with large high density type lipoproteins (HDL) (2,3). The human apoL family maps to chromosome 22q12.1-13.1 within a 127,000-bp region (4). ApoL has been characterized as a pancreas specific, 383-amino acid protein that contains a 12-amino acid secretory signal peptide (4). The apoL genes have TATA-less promoters and contain putative sterol regulatory elements, suggesting that transcription of these genes may be coordinated with that of the low density lipoprotein receptor and genes in pathways involving the synthesis of triglycerides and cholesterol (3). ApoL homologs can undergo 10 fold changes in expression during atherosclerotic changes in vascular endothelial cells, which includes the inflammatory reaction of atherosclerotic lesions (5).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
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仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： APOL1; Apo-L;APOL;Apolipoprotein L1;APOLI;Apolipoprotein L I;FSGS4;APOL1_HUMAN;
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