Rabbit Anti-IRF6 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:IRF6
IR:Immunogen Range:1-100/467
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3664
Swiss Prot:O14896
Source:KLH conjugated synthetic peptide derived from human IRF6:1-100/467
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 gamma p48 and IFN consensus sequence-binding protein (ICSBP).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Rabbit
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： IRF6;Interferon regulator;LPS;OFC6;OTTHUMP00000034677;OTTHUMP00000034678;PPS1;IRF6_HUMAN;
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