中文名：D-赤型鞘氨醇-1-磷酸
英文名：D-erythro-sphingosine-1-phosphate
应用：A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
纯度：Moligand™，≥98%
货号：D130606
Cas号：26993-30-6
存储温度：-20°C储存,充氩
运输条件：超低温运输
产品介绍：
D-erythro-Sphingosine-1-phosphate(S1P) is a polar sphingolipid metabolite which regulates diverse cellular responses including cell growth, survival and migration. S1P was reported to stimulate DNA synthesis and cell division in quiescent cultures of Swiss 3T3 fibroblasts and to trigger the dual signal transduction pathways of calcium mobilization and PC-PLD (phospholipase D) activation. S1P serves as a second messenger for intracellular calcium mobilization in U-937 cells and decreases cellular cAMP. Recent studies show that S1P is a G-protein-coupled receptor (GPCR) ligand for the EDG-1 family, including EDG-1, -3, -5, -6 and -8. This bioactive lipid mediator has been shown to stimulate the ERK pathway and to also counteract the ceramide-induced activation of stress-activated protein kinase (SAPK/JNK). Researchers have also found that S1P is a strong inhibitor of cell motility and phagokinesis in B16 melanoma cells. Additionally, it induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells. S1P has also been known as a tumor-promoting lipid. Sμggested to be an activator of GPR3, GPR6, and GPR12. D-erythro-Sphingosine-1-phosphate is an activator of EDG-1, EDG-3, EDG-2, EDG-4 and EDG-5.A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/D130606.html
关键字： (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate ; 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)- ; 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (R-(R*,S*-(E)))- ; Sphingosine 1-phosphate, >=95%, pow
阿拉丁（A股科创板上市企业，股票代码：688179） 是科研服务领域的领先供应商与制造商，拥有科学服务领域领导品牌：阿拉丁。核心业务涵盖高端化学与生化试剂、生命科学、小分子及化合物库及材料科学四大领域，并自主拥有“芯硅谷”实验耗材品牌，依托电商平台实现线上主导的销售模式 。产品广泛服务于985/211高校、科研院所及生物医药、化工材料等领域220余家A股上市公司。
国内以上海化工园区、奉贤基地为核心，建成超7.6万㎡现代化产业集群 ，拥有GMP车间满足高品质多元需求，并配备全国五大仓储中心。研发投入超3亿元，建有化学、生物两大研发中心，每年推出超10,000种新产品，截至2025年10月拥有178项知识产权 ，产品SCI引用超25.3万篇，稳居国内科研试剂文献TOP3 。
战略立足全球，已在美国、德国等多地设5个公司布局 ，连续获《国家级专精特新“小巨人”企业》 、《中国化学试剂十强企业》 、《最受用户欢迎试剂品牌》 等荣誉，秉承“推动发现，推进科学”的理念，助力科研创新。