aladdin 阿拉丁 P412422 PF-04995274 1331782-27-4 98%

中文名：PF-04995274

英文名：PF-04995274

纯度：Moligand™，≥98%

货号：P412422

Cas号：1331782-27-4

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist ofserotonin 4 receptor (5-HT4R)with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.

Targets

human 5-HT4E (Cell-free assay); human 5-HT4B (Cell-free assay); human 5-HT4D (Cell-free assay); human 5-HT4A (Cell-free assay); rat 5-HT4S (Cell-free assay) 32770,0.26 nM(EC50); 0.36 nM(EC50); 0.37 nM(EC50); 0.47 nM(EC50); 0.59 nM(EC50)

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