aladdin 阿拉丁 A287760 Adaptaquin,HIF-脯氨酰羟化酶2（PHD2）抑制剂 385786-48-1 ≥97%(HPLC)

中文名：Adaptaquin,HIF-脯氨酰羟化酶2（PHD2）抑制剂

英文名：Adaptaquin

纯度：≥97%(HPLC)

货号：A287760

Cas号：385786-48-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Product introduction

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

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