中文名：Tirasemtiv (CK-2017357)
英文名：Tirasemtiv (CK-2017357)
纯度：Moligand™，≥98%
货号：T412233
Cas号：1005491-05-3
存储温度：避光,-20°C储存
运输条件：超低温运输
产品介绍：
An orally bioavailable, non-toxic imidazopyrazinol compound that directly and selectively binds to the troponin complex in fast skeletal muscle (Kd = 40 nM) and sensitizes it to calcium. Its binding site is believed to be between two or more troponin subunits. Exhibits very modest affinity for slow skeletal muscle troponin (Kd = 3.8 µM) and has no measurable affinity for cardiac muscle troponin. Effectively stimulates myosin ATPase activity in fast skeletal muscle (EC50 = 390 nM), but has significantly reduced effect on mixed fiber type (EC50 = 770 nM in bovine rectus abdominis muscle). Slows the first order rate constant for Ca2+ release by about 70% (from 14.7 s-1 to 4.0 s-1) and shifts the plot of myosin ATPase relationship to calcium leftwards in fast skeletal muscles without increasing the maximum recorded force or the shape of the curve. Shown to improve muscle function in a rodent model of neuromuscular disease where neural input is diminished.
An orally bioavailable, non-toxic imidazopyrazinol compound that directly and selectively binds to the troponin complex in fast skeletal muscle (Kd = 40 nM) and sensitizes it to calcium. Its binding site is believed to be between two or more troponin subunits. Exhibits very modest affinity for slow skeletal muscle troponin (Kd = 3.8 µM) and has no measurable affinity for cardiac muscle troponin. Effectively stimulates myosin ATPase activity in fast skeletal muscle (EC50 = 390 nM), but has significantly reduced effect on mixed fiber type (EC50 = 770 nM in bovine rectus abdominis muscle). Slows the first order rate constant for Ca2+ release by about 70% (from 14.7 s-1 to 4.0 s-1) and shifts the plot of myosin ATPase relationship to calcium leftwards in fast skeletal muscles without increasing the maximum recorded force or the shape of the curve. Shown to improve muscle function in a rodent model of neuromuscular disease where neural input is diminished.
Information
Tirasemtiv (CK-2017357, CK-357) is a directfast skeletal muscle troponinactivator that sensitizes the sarcomere to calcium.
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/T412233.html
关键字： 提拉塞姆蒂夫 (CK-2017357);1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-one ; AC-35962 ; RSQGZEAXODVTOL-UHFFFAOYSA-N
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