中文名：PQR620
英文名：PQR620
纯度：≥97%
货号：P414179
Cas号：1927857-56-4
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
PQR620 is a novel, selective, orally bioavailable and brain penetrant dualTORC1/2inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
Targets
TORC1 (Cell-based assay); TORC2 (Cell-free assay) 250 nM; 250 nM
In vitro
PQR620 is a novel brain penetrant dual TORC1/2 inhibitor with anti-tumor activity across 56 lymphoma cell lines with a median IC50 value of 250 nM after 72 h of exposure.
In vivo
PQR620 has in vivo anti-lymphoma activity and in vivo synergism with the BCL2 inhibitor venetoclax. The combination of PQR620 and venetoclax have stronger in vivo anti-tumor activity than the single agents in a xenograft model of GCB-DLBCL.
Cell Research(from reference)
Cell lines：56 lymphoma cell lines, ABC-DLBCL cell lines (TMD8, Ri-1), GCB-DLBCL cell lines (OCI-LY-1,SU-DHL-6, DoHH2)
Concentrations：2 μM
Incubation Time：24 h, 72 h
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/P414179.html
关键字： 2-?Pyridinamine,5-?[4,?6-?bis(3-?oxa-?8-?azabicyclo[3.2.1]?oct-?8-?yl)?-?1,?3,?5-?triazin-?2-?yl]?-?4-?(difluoromethyl)?-
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。