aladdin 阿拉丁 O414422 奥拉布替尼（ICP-022） 1655504-04-3 98%

中文名：奥拉布替尼（ICP-022）

英文名：Orelabrutinib (ICP-022)

纯度：Moligand™，≥98%

货号：O414422

Cas号：1655504-04-3

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Orelabrutinib (ICP-022) Orelabrutinib (ICP-022) is a potent, orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK) . Orelabrutinib has potential antineoplastic activity.

Targets

BTK

In vitro

Orelabrutinib potently inhibits BTK enzymatic activity with an IC50 value of 1.6 nM. In KINOMEscan assay conducted in parallel at 1 μM against a panel of 456 kinases, orelabrutinib only targets BTK with > 90% inhibition while ibrutinib inhibits additional many other kinases including EGFR, TEC and BMX, demonstrating orelabrutinib\'s superior kinase selectivity.

In vivo

Orelabrutinib has a favorable PK profile with an ideal T1/2 (~1.5-4 h) and good oral bioavailability (~20-80%) as well as prolonged BTK target occupancy in preclinical PK/PD studies. The superior selectivity translates into improved safety profile and large safety window in the GLP toxicology studies in rats and dogs.

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/O414422.html