aladdin 阿拉丁 N414150 Naporafenib 1800398-38-2 98%

中文名：Naporafenib

英文名：Naporafenib

纯度：Moligand™，≥98%

货号：N414150

Cas号：1800398-38-2

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits bothB- and CRAF kinaseactivities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.

Targets

B-Raf ; C-Raf

In vitro

LXH254 not only inhibits MAPK signaling activity in tumor models harboring BRAFV600 mutation, but also inhibits mutant N- and KRAS-driven signaling due to its ability to inhibit both RAF monomers and dimers with similar potencies. LXH254 is orally bioavailable, demonstrates a direct PK/PD relationship and causes tumor regression in multiple cell line and primary human tumor derived xenograft models at well-tolerated doses.

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