中文名：ZT-12-037-01
英文名：ZT-12-037-01
纯度：≥99%
货号：Z414230
Cas号：2328073-61-4
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
ZT-12-037-01 ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.
Targets
STK19 (Cell-free assay); STK19 (D89N) (Cell-free assay) 23.96 nM; 27.94 nM
In vitro
ZT-12-037-01 treatment efficiently inhibits phosphorylation of NRAS in a dose- and time-dependent manner. Furthermore, with increasing ATP concentrations, the IC50 of ZT-12-037-01 against STK19 accordingly increased, indicating that ZT-12-037-01 is an ATP-competitive inhibitor for STK19. ZT-12-037-01 treatment significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation, proliferation, and tumor formation. Pro-apoptotic effect of ZT-12-037-01 is dramatically enhanced in cells expressing oncogenic NRAS.
In vivo
ZT-12-037-01 is a highly potent STK19 inhibitor with low in vivo toxicity. Its treatment also inhibits growth of SK-MEL-2 xenograft melanoma (with NRASQ61R) in a dose-dependent manner.
Cell Research(from reference)
Cell lines：A375, UACC62, SK-MEL-2 and WM2032 cells
Concentrations：0 μM, 1 μM, or 3 μM
Incubation Time：4 days
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/Z414230.html
关键字： ZT-12-037-01;ZT-12-037-01;2328073-61-4
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。