aladdin 阿拉丁 P413486 PF-6260933 1811510-56-1 98%

中文名：PF-6260933

英文名：PF-6260933

纯度：≥98%

货号：P413486

Cas号：1811510-56-1

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.

Targets

MAP4K4 3.7 nM

In vitro

PF-6260933 demonstrates good physicochemical properties as well as moderate human liver microsomal (HLM) clearance.

In vivo

Following oral dosing (10 mg/kg), PF-6260933 displays a plasma exposure that provided free drug concentrations above the cell IC50 value for about 4-6 h after administration in a mouse model. PF-6260933 has suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes.

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