中文名：依美斯汀
英文名：Emedastine
纯度：Moligand™，≥97%
货号：E413308
Cas号：87233-61-2
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Emedastine is a potent, high affinityhistamine H1-receptor-selectiveantagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).
Targets
H1 receptor (Cell-free assay) 1.3 nM(Ki)
In vitro
Emedastine is capable of potently inhibiting histamine-induced cytokine release as well as the chemotaxis of eosinophils, thereby influencing factors contributing to the inhibition of the signs and symptoms of allergic diseases.
In vivo
In human, the half-life of emedastine, when administered as slow release capsules is of about 6±7 h.
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关键字： 依美司丁;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole ; 1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)-1H-benzoimidazole ; 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
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