中文名：GSK2983559（化合物3）
英文名：GSK2983559 (compound 3)
纯度：Moligand™，≥98%
货号：G414274
Cas号：1579965-12-0
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
GSK2983559 (compound 3) GSK2983559 (compound 3, RIP2 kinase inhibitor 1, RIPK2-IN-1) is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity.
Targets
RIP2 kinase
In vitro
In a screen against nonkinase targets (Eurofins, 104 receptor and ion channel binding assays and 35 enzyme and cell-based assays), GSK2983559 is highly selective, inhibiting only melatonin receptor MT3 at a concentration under 10 μM..
In vivo
Administration of GSK2983559 at the 7.5 and 145 mg/kg b.i.d doses exhibits efficacy similar to that of prednisolone as measured by summed colon scores in a murine 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced colitis model..
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关键字： MFCD30489430 ; [2-({4-[(1,3-benzothiazol-5-yl)amino]-6-(2-methylpropane-2-sulfonyl)quinazolin-7-yl}oxy)ethoxy]phosphonic acid ; GSK2983559 (compound 3) ; SCHEMBL15578200
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