中文名：奥扎莫德（RPC1063）
英文名：Ozanimod (RPC1063)
纯度：Moligand™，≥98%
货号：O413886
Cas号：1306760-87-1
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Ozanimod (RPC1063) Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.
Targets
S1P1R (Cell-free assay); S1P5R (Cell-free assay) 0.41 nM(EC50); 11 nM(EC50)
In vitro
In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation.
In vivo
Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses clinical symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits clinical and histological disease scores. In a Naïve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness.
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关键字： HY-12288 ; 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile ; D10968 ; DTXSID501026488
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