aladdin 阿拉丁 M414494 MCU-i4 371924-24-2 99%

中文名：MCU-i4

英文名：MCU-i4

纯度：≥99%

货号：M414494

Cas号：371924-24-2

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Information

MCU-i4 MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.

Targets

MCU1

In vitro

MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft.

Cell Research(from reference)

Cell lines：C2C12 myoblasts 

Concentrations：10 μM 

Incubation Time：24 h 

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