aladdin 阿拉丁 S275697 SR-9009,REV-ERBα/β激动剂 1379686-30-2 98%

中文名：SR-9009,REV-ERBα/β激动剂

英文名：SR-9009

纯度：Moligand™，≥98%

货号：S275697

Cas号：1379686-30-2

存储温度：避光,-20°C储存,干燥

运输条件：超低温运输

产品介绍：

储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。

A pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.

SR9009 是 REV-ERBα/β 激动剂，作用 REV-ERBα 和 REV-ERBβ 的 IC50 分别为 670 nM 和 800 nM。

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