中文名：HS-243
英文名：HS-243
纯度：10mM in DMSO
货号：H580413
Cas号：848249-10-5
存储温度：-80℃储存
运输条件：特低温运输
产品介绍：
Information
HS-243 HS-243 is a highly potent interleukin-1 receptor-associated kinase (IRAK) inhibitor with IC50 of 24 nM, 20 nM and 0.5 μM for IRAK-1, IRAK-4 and TAK1, respectively.
Targets
IRAK-4 (Cell-free assay); IRAK-1 (Cell-free assay); TAK1 (Cell-free assay) 20 nM; 24 nM; 0.5 μM
In vitro
HS-243 has exquisite selectivity toward both IRAK-1 (IC50 = 24 nM) and IRAK-4 (IC50 = 20 nM), with only minimal TAK1-inhibiting activity (IC50 = 0.5 μM). Using HS-243 and takinib, we evaluates the consequences of cytokine/chemokine responses after selective inhibition of IRAK-1/4 or TAK1 in response to lipopolysaccharide challenge in human rheumatoid arthritis fibroblast-like synoviocytes. HS-243 specifically inhibits intracellular IRAKs without TAK1 inhibition and these kinases have distinct, nonredundant signaling roles.
Cell Research(from reference)
Cell lines：RA-FLS cells, THP-1 cells
Concentrations：10 μM
Incubation Time：24 h
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关键字： (E)-3-nitro-N-(1-propyl-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide
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