中文名：Emavusertib (CA-4948)
英文名：Emavusertib (CA-4948)
纯度：Moligand™，≥99%
货号：E414483
Cas号：1801344-14-8
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Emavusertib (CA-4948) Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity.
Targets
IRAK4 ; FLT3
In vitro
Emavusertib (CA-4948) is over 500-fold more selective for IRAK-4 compared to IRAK-1. Emavusertib (CA-4948) reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. Emavusertib (CA-4948) has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3.
In vivo
Emavusertib (CA-4948) has anti-tumour activity in animal models including tumours containing MyD88 gene mutations.
Cell Research(from reference)
Cell lines：THP-1 cells
Concentrations：0.1 μM-10 μM
Incubation Time：60 min
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/E414483.html
关键字： GTPL10152 ; RCRA waste no. P108 ; AU4948 ; AU-4948
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