aladdin 阿拉丁 A409120 ABBV-744 2138861-99-9 10mM in DMSO

中文名：ABBV-744

英文名：ABBV-744

纯度：Moligand™，≥99%

货号：A414135

Cas号：2138861-99-9

存储温度：-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.

Targets

BDII

In vitro

ABBV-744 is a potent inhibitor specific for BDII of BRD2/3/4, with >250-fold differential binding preference for BDII over BDI and excellent drug-like properties. ABBV-744 is also a potent and selective inhibitor of the AR (androgen receptor) transcription pathway.

In vivo

doses of ABBV-744 at fractions of its maximum tolerated dose (MTD) induces tumor growth inhibition in AML and prostate cancer xenograft models that were comparable to those observed with ABBV-075 when dosed at its MTD.

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