中文名：Ochromycinone (STA-21)
英文名：Ochromycinone (STA-21)
纯度：≥98%
货号：O413885
Cas号：111540-00-2
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Application：
STA-21 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor to study its effects on glioblastoma and primary glioblastoma cells. It has also been used as a STAT3 dimerization inhibitor to study its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) production in human lung cancer cell line.
Information
Ochromycinone (STA-21) is a selectiveSTAT3inhibitor.
Targets
STAT3
In vitro
In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.
In vivo
In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.
Cell Research(from reference)
Cell lines：MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, MCF7, and Caov-3 cells
Concentrations：20 or 30 μM
Incubation Time：48 h
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/O413885.html
关键字： 奥色霉素 (STA-21);HY-18061 ; NSC628869 ; NSC-628869
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