中文名：Omaveloxolone (RTA-408)
英文名：Omaveloxolone (RTA-408)
纯度：Moligand™，≥98%
货号：O413808
Cas号：1474034-05-3
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
Targets
NF-κB ; Nrf2
In vitro
RTA 408 potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, RTA 408 inhibits growth with an average GI50 value of 260 nM and induces apoptosis. RTA 408 also inhibits NF-κB and activates JNK in tumor cells.
In vivo
In mice with radiation-induced dermatitis, 1.0% RTA 408 markedly reduces epidermal and collagen thickening, prevents dermal necrosis and completely alleviates skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also mitigates hematopoietic acute radiation syndrome in mice.
Cell Research(from reference)
Cell lines：A375, NCI-H460, A2058, MDA-Mb-231, HCT116, 786-0, A549, and PANC-1 cells
Concentrations：~1 μM
Incubation Time：72 hours
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/O413808.html
关键字： N-(2-氰基-3,12-二氧代-28-去甲齐墩果-1,9(11)-二烯-17-基)-2,2-二氟丙酰胺 ; 奥马维洛酮 (RTA-408);DTXSID101138251 ; GTPL7573
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