BMP-2产品信息
英文名称：Bone morphogenetic protein 2
中文名称：骨形态生成蛋白2
靶点别称：BMP2,BMP2A
物种：Human
标签：Tag Free
属性：Protein
标记：Unconjugated
表达区间及表达系统（Source）
Human BMP-2 Protein, premium grade (BM2-H4117) is expressed from E. coli cells. It contains AA Ala 284 - Arg 396 (Accession # NP_001191 ).
Predicted N-terminus: Met
It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.
蛋白结构（Molecular Characterization）
This protein carries no "tag"
The protein has a calculated MW of 12.8 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).
内毒素（Endotoxin）
Less than 0.2 EU per μg by the LAL method.
无菌（Sterility）
The sterility testing was performed by membrane filtration method.
纯度（Purity）
>95% as determined by SDS-PAGE.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in 100 mM Acetic Acid, pH2.8 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
BMP-2分子背景
人骨形态发生蛋白2（BMP2）也称为人BMP-2、BMP-2、BMP 2、BMP2、h-BMP-2、rh-BMP-2、重组人BMP-2，重组BMP-2，BMP，是属于结构相关信号蛋白TGF-b超家族的BMP亚组的成员。BMP-2是一种强效的骨诱导细胞因子，能够与胶原和合成羟基磷灰石等骨传导载体结合诱导骨和软骨形成。除了其成骨活性外，BMP-2在心脏形态发生中起着重要作用，并在肺、脾、脑、肝、前列腺、卵巢和小肠等多种组织中表达。正如其名称所暗示的那样，BMPs在眼睛、心脏、肾脏、皮肤和其他组织的产前发育和产后生长中促进和调节骨骼发育、生长、重塑和修复。BMP2已被证明能有效诱导多种细胞类型的成骨细胞分化，并作为一种新功能诱导人骨髓瘤细胞系凋亡。
关键字： BMP-2;BMP-2蛋白;BMP2;BMP2蛋白;骨形态生成蛋白2;
百普赛斯集团ACROBiosystems Group（股票代码：301080）是成立于2010年的跨国生物科技公司，是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球，横跨亚洲、北美洲、欧洲，在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家，与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。