Product Name：DOTA-LM3
CAS No.：1192362-32-5
Synonyms：生长抑素受体(SSTR)拮抗剂多肽DOTA-LM3
Catalog No.：218P632
Brand：HongTide（上海鸿肽生物）
Description：DOTA-LM3是一种生长抑素受体 (SSTR) 拮抗剂多肽，序列中含有8个氨基酸。DOTA-LM3通常通过同位素标记，如177Lu-DOTA-LM3和68Ga-DOTA-LM3，进行体内肿瘤示踪。68Ga-DOTA-LM3显示出有优异的生物分布特性、高度的肿瘤摄取能力、稳定的肿瘤内保留及较低的安全风险。而177Lu-DOTA-LM3则被用于研究DOTATOC阴性的肝转移案例，针对胰腺NET和广泛性的肿瘤血栓形成治疗具有潜在应用价值。
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist peptide with a sequence containing 8 amino acids. DOTA-LM3 is typically used for in vivo tumor tracing through isotope labeling, such as 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. 68Ga-DOTA-LM3 exhibits excellent biological distribution characteristics, high tumor uptake capacity, stable intratumoral retention, and lower safety risks. 177Lu-DOTA-LM3 was used to study DOTATOC negative liver metastasis cases, which has potential application value in the treatment of pancreatic NET and widespread tumor thrombosis.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DOTA-{p-Cl-Phe}-{D-Cys}-Y-{D-4-amino-Phe(carbamoyl)}-KTC-{D-Tyr}-NH2（Disulfide bridge:Cys2-Cys6） |
Sequence(3-letter code) | DOTA-{p-Cl-Phe}-D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys-D-Tyr-NH2（Disulfide bridge:Cys2-Cys6） |
Peptide Structure |  |
Molecular Formula | C69H93ClN16O19S2 |
Molecular Weight | 1550.16 |
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上海鸿肽生物科技有限公司
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关键字： 1192362-32-5;DOTA-LM3;生长抑素受体(SSTR)拮抗剂多肽DOT;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。