Product Uses Include
Analysis of in vivo Rac1 activation levels
Detection of compounds and proteins that enhance Rac1 activity
Detection of compounds and proteins that inhibit Rac1 activity
The activity of Rac1 in cells (tissues) was studied qualitatively
Product Description
Background:
Small GTPases are a super-family of cellular signaling regulators. Rac belongs to the Rho sub-family of GTPases that
regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Rac, and the hydrolysis
of GTP to GDP renders it inactive. GTP hydrolysis is ai ded by GTPase activating proteins (GAPs), while exchange of
GDP for GTP is facilitated by guanine nucleotide exchange factors
Tested Applications: IP/WB
Tested Applications: IHF
Tested Applications: IHC
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