中文名：平滑激动剂（SAG）盐酸
英文名：Smoothened Agonist (SAG) HCl
纯度：≥99%
货号：S413830
Cas号：2095432-58-7
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
Smoothened Agonist (SAG) HCl is a cell-permeableSmoothened(Smo) agonist withEC50of 3 nM in Shh-LIGHT2 cells.
Targets
Smoothened (mouse cultured cell assay) 3 nM(EC50)
In vitro
SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
In vivo
In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
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关键字： SAG hydrochloride ; N-(3-(pyridin-4-yl)benzyl)-3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide hydrochloride
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