aladdin 阿拉丁 S414446 SP-96 2682114-54-9 99%

中文名：SP-96

英文名：SP-96

纯度：≥99%

货号：S414446

Cas号：2682114-54-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

SP-96 is a potent, selective and non-ATP-competitive inhibitor ofAurora Bwith IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).

Targets

Aurora B (Cell-free assay) 0.316 nM

In vitro

SP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line.

Cell Research(from reference)

Cell lines：MCF-7 cells 

Incubation Time：24 h 

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