中文名：RO9021
英文名：RO9021
纯度：≥95%
货号：R413732
Cas号：1446790-62-0
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
RO9021 RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.
Targets
Syk (Cell-free assay) 5.6 nM
In vitro
RO9021 suppresses BCR signaling in human peripheral blood mononuclear cells (PBMC) and whole blood, FcγR signaling in human monocytes, and FcεR signaling in human mast cells and blocks osteoclastogenesis from mouse bone marrow macrophages in vitro. Toll-like Receptor(TLR) 9 signaling in human Bcells was inhibited by RO9021, resulting in decreased levels of plasmablasts, immunoglobulin (Ig)M and IgG upon B-cell differentiation. RO9021 also potently inhibited type I interferon production by human plasmacytoid dendritic cells (pDC) upon TLR9 activation. This effect is specific to TLR9 as RO9021 did not inhibit TLR4- or JAK-STAT-mediated signaling. RO9021 does not appreciably inhibit the JAK-STAT pathway.
In vivo
Oral administration of RO9021 inhibits arthritis progression in the mCIA model.
Cell Research(from reference)
Cell lines：Human B-cell line, Ramos
Concentrations：1 μM
Incubation Time：5 or 15 min
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关键字： 3-?Pyridazinecarboxamid?e,6-?[[(1R,?2S)?-?2-?aminocyclohexyl]?amino]?-?4-?[(5,?6-?dimethyl-?2-?pyridinyl)?amino]?-
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