中文名：CB1954
英文名：CB1954
纯度：≥98%
货号：C413845
Cas号：21919-05-1
存储温度：-20°C储存
运输条件：超低温运输
产品介绍：
Information
CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into apotent cytotoxic bifunctional alkylating agent. It can be activated byNAD(P)H quinone oxidoreductase 2.
In vitro
The overexpression of nitroreductase oxidored nitro domain containing protein 1 (NOR1) is capable of converting the monofunctional alkylating agent CB1954 into a toxic form by reducing the 4 nitro group of CB1954 which is a potent cytotoxins. Toxic CB1954 enhances cells killing in the NPC cell line CNE1. the NOR1 gene enhances CB1954 mediated cell cytotoxicity through the upregulation of Grb2 expression and the activation of MAPK signal transduction in the HepG2 cell line
In vivo
The NTR/CB1954 system are used to specific ablation of cells in vivo. The effect of this inducible ablation system is dose-dependent. NTR-mediated cell killing by CB1954 does not require cell proliferation. The activated CB1954 cross-links DNA which presumably triggers the apoptosis cascade, resulting in rapid cell death. specific and effective cells killing by NTR-CB1954 does not require a functional p53.
Cell Research(from reference)
Concentrations：4-10 μmol/L
Application
CB 1954 has been used in drug-induced ablation studies.
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/C413845.html
关键字： EU-0100200 ; HY-13543 ; Lopac0_000200 ; 2,4-Dinitro-5-ethyleneiminobenzamide
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。