aladdin 阿拉丁 D413068 紫花前胡醇当归酯 130848-06-5 98%

中文名：紫花前胡醇当归酯

英文名：Decursinol angelate

纯度：≥98%

货号：D413068

Cas号：130848-06-5

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

Information

Decursinol angelate Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

Targets

PKC

In vitro

Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3\'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells.

In vivo

Decursinol angelate has anti-angiogenic activity both in vitro and in vivo.

Cell Research(from reference)

Cell lines：MCF-7 cells 

Concentrations：10 μM, 20 μM, 50 μM 

Incubation Time：24 hours 

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