GDNF产品信息
英文名称:Glial cell line-derived neurotrophic factors
中文名称:神经胶质细胞系衍生神经营养因子类
靶点别称:GDNF,ATF
物种:Human/Mouse
属性:Protein
标记:Unconjugated
内毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
无菌(Sterility)
The sterility testing was performed by membrane filtration method.
支原体(Mycoplasma)
Negative.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

GDNF分子背景
胶质细胞源性神经营养因子(GDNF)是一种神经营养因子,可增强多巴胺能神经元的存活和形态分化,并增加其高亲和力多巴胺摄取。GDNF是一种糖基化、二硫键合的同二聚体,是转化生长因子β超家族的远亲。GDNF家族成员(由GDNF、neurturin、artemin和persephin组成)在结构上与转化生长因子β相似。与通过受体丝氨酸-苏氨酸激酶发出信号的TGF-β超家族的其他成员不同,GDNF家族配体通过受体酪氨酸激酶Ret激活细胞内信号级联。GDNF家族配位体结合GDNF家族受体α(GFRalpha),然后GDNF家族-配体-GFR-alpha复合物结合并刺激Ret的自磷酸化。

关键字: GDNF;GDNF蛋白;ATF蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。