Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free
分子别名(Synonym)
α-synuclein,NACP, PARK1, PARK4, PD1
表达区间及表达系统(Source)
Human Alpha-Synuclein Pre-formed Fibrils, Tag Free (ALN-H5115) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Predicted N-terminus: Met 1
蛋白结构(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 14.5 kDa.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
运输(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C;
The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions;
The sonicated fibril should be stored at -70°C for not more than 8 weeks.

背景(Background)
α-突触核蛋白是一种神经元蛋白,在突触活动中起着多种作用,如调节突触小泡的运输和随后的神经递质释放。它在多聚体膜结合状态下也充当分子伴侣,协助突触前质膜上称为SREs(可溶性NSF附着蛋白受体)的突触融合成分与半胱氨酸串蛋白α/DJC5结合折叠。α-突触核蛋白的异常与帕金森病(PD)的发病机制有关。α-突触核蛋白存在于路易体内,这是帕金森病的神经病理学标志,该蛋白及其聚集与最终导致神经退行性变的神经毒性途径广泛相关。
关键字: α-synuclein;α突触核蛋白;α-synuclein蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。