Human FGFR1 / CD331 Protein, His Tag (SPR verified)
分子别名(Synonym)
FGFR1,BFGFR,CD331,CEK,FGFBR,FLG,HBGFR,N-SAM,FLT2,H2,KAL2,FLJ14326
表达区间及表达系统(Source)
Human FGF R1, His Tag (FG1-H5223) is expressed from human 293 cells (HEK293). It contains AA Arg 22 - Ile 376 (Accession # P11362-7).
Predicted N-terminus: Arg 22
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 41.2 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
成纤维细胞生长因子受体1(FGFR1)也称为碱性成纤维细胞增长因子受体1,FMS样酪氨酸激酶,CD331,是一种受体酪氨酸激酶,其配体是成纤维细胞成长因子家族的特定成员。这种蛋白质是几种成纤维细胞生长因子受体之一,这些受体是参与细胞分裂、细胞生长和成熟调节、血管形成、伤口愈合和胚胎发育等重要过程的相关蛋白质。FGFR1蛋白横跨细胞膜,因此蛋白的一端留在细胞内,另一端从细胞外表面伸出。这种定位允许FGFR1蛋白与细胞外的特定生长因子相互作用,并接收有助于细胞对其环境作出反应的信号。当生长因子附着在FGFR1蛋白上时,受体会在细胞内引发一系列化学反应,指示细胞发生某些变化,例如成熟以承担特定的功能。FGFR1蛋白被认为在神经系统的发育中起着重要作用。这种蛋白质也可能有助于调节长骨的生长,如手臂和腿部的大骨头。
关键字: FGFR1;FGFR1蛋白;FGFR1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。