PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin)
抗体来源(Source)
Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293),which provides higher batch consistency and long term security of supply. It shows superior performance in flow cytometry assays with higher affinity and better specificity.
应用(Application)
Flow Cytometry (Evaluation of cell surface expressed CARs of varying specificity containing a G4S linker within the scFv of the extracellular domain).
克隆号(Clone)
016
种属(Species)
Rabbit
亚型(Isotype)
Rabbit IgG | Rabbit Kappa
特异性(Specificity)
Specifically recognizes the scFv-based CARs containing a G4S linker.
偶联(Conjugate)
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
推荐稀释比(Recommended Dilution)
1:50
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.03% Proclin 300, pH7.4, 0.2% BSA with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months after reconstitution.
2-8°C for 12 months after reconstitution.


背景(Background)
G4S linker是单链抗体最常见的连接肽。它由重复序列(Gly-Gly-Gly-Gly-Ser)组成,通常在scFv片段中以15-mer(G4S)3或20-mer(G4S)4的形式存在。G4S linker已成为绝大多数CAR不可或缺的一部分,因为它连接scFvs的VH和VL识别结构域。G4S linker通常用于靶向实体瘤抗原(如HER2和CEA)的CAR,而惠特洛/218接头肽主要用于靶向血液系统恶性肿瘤(如CD19 CAR产物)的CAR构建。
关键字: G4S linker;G4S linker抗体;Anti-G4S linker;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。