| 名称 | S-Methylisothiourea sulfate |
| 描述 | S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. |
| 动物实验 | S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1]. |
| 体外活性 | S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1]. |
| 体内活性 | S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1]. |
| 存储条件 | Keep away from moisture,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 60 mg/mL (431.1 mM), Sonication is recommended.
DMSO : < 1 mg/mL (insoluble or slightly soluble)
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| 关键字 | S-Methylisothiourea Sulfate | SMethylisothiourea sulfate | S-Methylisothiourea | shock | septic | S Methylisothiourea sulfate | pressure | NOSynthase | NOS | NO Synthase | Nitric oxide synthases | Methylisothiourea Sulfate | iNOS | Inhibitor | inhibit | hypotension | HSV | Herpes simplex virus | circulatory | blood |
| 相关产品 | Oxyresveratrol | Vidarabine | Aminopicoline | Diallyl disulfide | 2-Deoxy-D-glucose | Methylene Blue trihydrate | Gluconate Calcium | Gluconate sodium | L-Lysine | L-Arginine | 2-Isopropyl-1H-imidazole | Magnesium sulfate |
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