| 名称 | Glucagon (1-29), bovine, human, porcine |
| 描述 | Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes. |
| 体外活性 | Glucagon (1-29), bovine, human, porcine 与其受体 Gcgr 结合后，激活 cAMP-PKA 信号通路，进而促进肝脏葡萄糖生成并引发高血糖症。此外，Glucagon (1-29), bovine, human, porcine 还能刺激肝脏产生 kisspeptin1 和糖异生。[1]
Glucagon (1-29), bovine, human, porcine 在 100 nM 浓度下抑制人原代肝细胞中 CYP7A1 mRNA 的表达，并增加 HNF4α 的磷酸化水平。[3] |
| 体内活性 | 低剂量的 20 μg/kg Glucagon (1-29), bovine, human, porcine 能够升高血糖，但不会刺激在正常环境中喂养的小鼠分泌胰岛素。与 PBS 对照相比，高剂量的 1 mg/kg Glucagon (1-29), bovine, human, porcine 可以降低血糖并刺激在正常环境中喂养的小鼠分泌胰岛素。[4] |
| 存储条件 | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 1 mg/mL (0.29 mM), Sonication is recommended.
H2O : 4 mg/mL (1.15 mM), when pH is adjusted to 2 with HCl. Sonication is recommmended.
|
| 关键字 | Porcine glucagon(1-29), bovine, human, porcine | GlucagonReceptor | Glucagon Receptor | Glucagon , bovine, human, porcine | Glucagon (129), bovine, human, porcine | Glucagon (1 29), bovine, human, porcine | GCGR |
| 相关产品 | 6α-Methylprednisolone 21-hemisuccinate sodium salt | Tirzepatide Acetate(2023788-19-2 free base) | PF-06882961 Tris | Semaglutide | LSN3318839 | Orforglipron | Exendin-4 acetate | MK-0626 | NNC 92-1687 | Exendin-4 | Liraglutide | (S, R)-LSN 3318839 |