APC-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag, premium grade (Site-specific conjugation)
分子别名（Synonym）
CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
表达区间及表达系统（Source）
APC-Labeled Human CLEC12A Protein, His Tag, premium grade (CLA-HA246) is produced via conjugation of APC to Human CLEC12A Protein, His Tag, premium grade with a new generation site-specific technology under optimal conditions with a proprietary technology. Human CLEC12A Protein, His Tag, premium grade is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).
Predicted N-terminus: Gly
该产品是在我们严格的质量控制体系下生产的，该体系包含一套全面的测试，包括无菌和内毒素测试。在早期临床前阶段，产品性能经过仔细验证和测试，以确保其与细胞培养用途或任何其他应用的兼容性。当准备过渡到后期临床阶段时，我们还提供定制的GMP蛋白质服务，以满足您的需求。我们将与您合作，根据您的要求定制和开发GMP级产品，该产品也符合细胞疗法细胞制造中使用的原材料和辅助材料的要求。
蛋白结构（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 27.3 kDa.
偶联（Conjugate）
APC
Excitation Wavelength: 640 nm
Emission Wavelength: 661 nm
应用说明（Application）
Please note that this product is NOT compatible to streptavidin detection system.
内毒素（Endotoxin）
Less than 0.1 EU per test by the LAL method.
无菌（Sterility）
Negative
支原体（Mycoplasma）
Negative.
制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, 0.5% rHSA, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution;
2-8°C for 12 months under sterile conditions after reconstitution.
背景（Background）
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
关键字： CLEC12A;CLEC12A蛋白;CLEC12A重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group（股票代码：301080）是成立于2010年的跨国生物科技公司，是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球，横跨亚洲、北美洲、欧洲，在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家，与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。