| 名称 | PACAP (1-27), human, ovine, rat acetate |
| 描述 | PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats. |
| 体外活性 | 通过对I-monoiodinated PACAP (1-27), human, ovine, rat进行放射配体受体结合实验，确认AR4-2J细胞表面存在PAC受体，因为PACAP (1-27), human, ovine, rat和PACAP(1–38)以相同的效力（Kd值为1-2 nM）置换放射配体的结合，而血管活性肠肽(VIP)的效力则低1000倍。PACAP (1-27), human, ovine, rat对VIP-氨基酸替换表现出明显更高的敏感性。在AR4-2J细胞中，PACAP (1-27), human, ovine, rat展现出促进IP3和cAMP生成的效能和结合亲和力。 |
| 体内活性 | 垂体腺苷酸环化酶激活多肽(PACAP (1-27), human, ovine, rat)对麻醉、通气的豚鼠总肺阻力(RL)增加的抑制作用进行了研究，该增加由过敏原或组胺引起。通过静脉输注给予PACAP (1-27), human, ovine, rat（剂量范围0.045-4.5 nmol/kg/min）能剂量依赖性地减少吸入卵清蛋白和组胺引起的RL增加。在最高剂量时，PACAP (1-27), human, ovine, rat完全阻止了由卵清蛋白和组胺引起的RL增加。PACAP (1-27), human, ovine, rat与β2-肾上腺素受体激动剂，沙丁胺醇（剂量范围0.045-4.5 nmol/kg/min）的输注同样抑制RL增加，但沙丁胺醇比PACAP (1-27), human, ovine, rat更能增加心率[3]。 |
| 存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 5 mM, Sonication is recommended.
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| 关键字 | PACAP 1-27 Acetate | PACAP , human, ovine, rat Acetate | PACAP (127), human, ovine, rat acetate | PACAP (1 27), human, ovine, rat acetate |
| 相关产品 | PACAP (1-27), human, ovine, rat TFA | PACAP 1-38 acetate | Thielocin B1 | PACAP-38 (31-38), human, mouse, rat acetate | PACAP (6-38), human, ovine, rat acetate | PA-8 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP-38 (16-38), human, mouse, rat | PACAP (1-38), human, ovine, rat | PAC1R antagonist 1 | PACAP (1-38), human, ovine, rat TFA | VIP(Guinea pig) |
| 相关库 | 多肽分子库 | NO PAINS 化合物库 |