化合物 Topoisomerase I inhibitor 5,Topoisomerase I inhibitor 5

化合物 Topoisomerase I inhibitor 5|T61501|TargetMol

价格	￥19420	￥24625	￥14900
包装	50mg	100mg	25mg

最小起订量	1mg
发货地	上海
更新日期	2025-11-17

QQ交谈微信洽谈

产品详情

中文名称:化合物 Topoisomerase I inhibitor 5	英文名称:Topoisomerase I inhibitor 5
CAS:2513461-95-3	品牌: TargetMol
产地: 美国	保存条件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
产品类别: 抑制剂
货号: T61501

Product Introduction

Bioactivity

名称	Topoisomerase I inhibitor 5
描述	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
体外活性	Topoisomerase I inhibitor 5 (compound 14) (0-50 μM; 48 hours) exhibits antiproliferation activity against cancer cell lines and lower cytotoxicity in normal cells [1]. Topoisomerase I inhibitor 5 (2-8 μM; 24 hours) induces MCF-7 cell cycle arrest at the G1 phase [1]. Topoisomerase I inhibitor 5 (2-8 μM; 48 hours) increases the apoptotic rate of MCF-7/ADR and MCF-7 cells [1]. Topoisomerase I inhibitor 5 (1.5-6 μM; 24 hours) increases the expression degree of cleaved-caspase-3 and cleaved-PARP in MCF-7; down-regulates the level of anti-apoptotic protein, up-regulates the levels of pro-apoptotic proteins in MCF-7/ADR [1]. Topoisomerase I inhibitor 5 (0.1 μM; 24 hours) induces cell apoptosis by promoting the accumulation of ROS in MCF-7/ADR cell [1]. Topoisomerase I inhibitor 5 (10 μg/ml; 24 hours) increases the accumulation of the ADR and Rh123 in MCF-7/ADR cells [1]. Topoisomerase I inhibitor 5 (5, 10 and 20 μM; 24 hours) reduces the expression degree of P-gp by 14.95% and 18.10% in MCF-7/ADR cells at 10 and 20 μM [1]. Cell Proliferation Assay Cell Line: A549, HepG-2, MCF-7, MDA-MB-231, MCF-7/ADR and LO2 cells [1] Concentration: 0-50 μM Incubation Time: 48 hours Result: Exhibited antiproliferation activity against cancer cell lines, with IC 50 s of 2.39 ± 0.23 μM, 4.88 ± 0.29 μM, 1.32 ± 0.14 μM, 7.64 ± 0.35 μM and 2.42 ± 0.14 μM in A549, HepG-2, MCF-7, MDA-MB-231, MCF-7/ADR, respectively; and has lower cytotoxicity in LO2 cells with IC 50 of 36.52 ± 2.36 μM. Cell Cycle Analysis Cell Line: MCF-7 [1] Concentration: 2, 4 and 8 μM Incubation Time: 24 hours Result: Induced MCF-7 cell cycle arrest at the G1 phase. Apoptosis Analysis Cell Line: MCF-7 and MCF-7/ADR cells [1] Concentration: 2, 4 and 8 μM Incubation Time: 48 hours Result: Induced apoptosis in a dose-dependent manner in MCF-7 cells, and increased the apoptotic rate of the cells from 2.8% to 15.2% in MCF-7/ADR. Western Blot Analysis Cell Line: MCF-7 [1] Concentration: 1.5, 3 and 6 μM in MCF-7; 5, 10, and 20 μM in MCF-7/ADR Incubation Time: 24 hours Result: Increased the expression degree of cleaved-caspase-3 and cleaved-PARP in MCF-7; down-regulated the level of anti-apoptotic protein bcl-2, up-regulated the levels of pro-apoptotic proteins bax and bad in MCF-7/ADR.
体内活性	Topoisomerase I inhibitor 5 (1 mg/kg and 10 mg/kg; IV; every two days, for 21 days) decreases the tumor growth significantly [1]. Animal Model: Bal b/c nude mice (injected with 106 MCF-7 cells in the left flank for 7 days) [1] Dosage: 1 mg/kg and 10 mg/kg Administration: IV; every two days, for 21 days Result: Decreased the tumor growth significantly and the tumor inhibition ratio reached to 32.4% at 1 mg/kg and 7.2% at 10 mg/kg.
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
相关产品	Guanidine hydrochloride \| Cysteamine hydrochloride \| Alginic acid \| 1,4-Naphthoquinone \| Metronidazole \| Dextran sulfate sodium salt (MW 5000) \| Citric Acid Triammonium \| Stavudine \| Adenine \| Cystamine dihydrochloride \| Thymidine \| Sodium 4-phenylbutyrate

关键字： Topoisomerase I inhibitor 5|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	2013-04-18 （13年）	注册资本	589.8595万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	中间体,天然产物,生物化工,化学试剂,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol中国（陶术生物）

VIP 2年

公司成立：13年
注册资本：589.8595万人民币
企业类型：有限责任公司(自然人投资或控股)
主营产品：抑制剂&激动剂，天然产物，重组蛋白，化合物库，技术服务
公司地址：上海市静安区江场三路238号8楼

进入店铺

询盘

店内推荐

化合物 OF-Deg-Lin|T84735|TargetMol

询价

EPhA2, Cynomolgus, 重组蛋白 (His & Avi)|TMPK-00979|TargetMol

￥12400

化合物 K-14585|T27708|TargetMol

￥29800

化合物 Topoisomerase I inhibitor 5|T61501|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
Topoisomerase II inhibitor 13—451515-89-2	询价	VIP4年	湖北魏氏化学试剂股份有限公司	2026-02-10
Topoisomerase I Rabbit Monoclonal Antibody	询价		碧云天生物技术有限公司	2026-02-15
化合物 KRAS G12D INHIBITOR 14 2765254-39-3	询价	VIP3年	陕西缔都新材料有限公司	2025-12-04

内容声明:
以上所展示的信息由商家自行提供，内容的真实性、准确性和合法性由发布商家负责。商家发布价格指该商品的参考价格，并非原价，该价格可能随着市场变化，或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格，请咨询商家，以实际成交价格为准。请意识到互联网交易中的风险是客观存在的