Human Nogo Receptor / NgR Protein, His Tag (SPR verified)
分子别名(Synonym)
Reticulon-4 receptor,Nogo-66 receptor
表达区间及表达系统(Source)
Human Nogo Receptor, His Tag (NOR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Ser 447 (Accession # Q9BZR6).
Predicted N-terminus: Cys 27
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.2 kDa. The protein migrates as 63-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
Nogo受体/网织红蛋白-4受体在调节成人中枢神经系统的轴突再生和神经元可塑性中起着重要作用。在出生后的大脑发育中发挥作用。轴突在大脑中线的正常迁移和胼胝体的正常形成所必需的。保护运动神经元免于凋亡;抗凋亡的保护作用可能是通过与MAG的相互作用介导的。在皮质发育过程中,与RTN4和LINGO1协同作用,调节神经元前体细胞的运动。与其他家庭成员一样,它在限制大脑发育过程中形成的树突棘数量和突触数量方面发挥着作用。
关键字: Nogo Receptor;Nogo Receptor蛋白;Nogo受体;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。